An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications

InNucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers.

The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field.

Readers will also find: A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry Comprehensive explorations of the methods used to determine the development of nucleic acid drugs Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry

Perfect for medicinal and nucleic acid chemists,Nucleic Acids in Medicinal Chemistry and Chemical Biologywill also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

Lihe Zhang is President of the Academic Committee of State Key Laboratory of Natural& Biomimetic Drugs and Professor of Medicinal Chemistry at Peking University.

Xinjing Tang is Professor of Medicinal Chemistry at Peking University.

Zhen Xi is Chairman of the Department of Chemical Biology, Deputy Director of the State Key Laboratory of Element-Organic Chemistry, Professor of Pesticide Science and Chemical Biology, and Vice Dean for Academic Affairs of the College of Chemistry at Nankai University.

Jyoti Chattopadhyaya is Chairman of the Department of Cell and Molecular Biology and Chair of Bioorganic Chemistry at the University of Uppsala.

Chapter 1. Phosph(on)ate Prodrugs-prof.Junbiao Chang.docx

chapter 2-Cyclic Dinucleotides A New Generation Drug for Immune Therapy-prof Xi.docx

Chapter 3-Enzymatic and Endogenous Synthesis of NAD(P)-derived Calcium-mobilizing Messengers-Prof Lee.docx

Chapter 4-Selenium Atom-modified Nucleic Acids for Structural, Functional and Diagnostic Studies-prof huang.docx

chapter 5-Sequence-specific chromosomal DNA binders an unfulfilled promise-Prof Sugiyama.docx

chapter 6- DNA synthesis and synthetic genome-prof Yuan.docx

Chapter 7-Methods for mapping of nucleic acids epigenetic modifications and its clinic applications-prof zhou.docx

Chapter 8-main text.docx

Chapter 9-nucleic acid-based nanocarriers as drug delivry system-Prof. Jongbum Lee-no figure.docx

Chapter 10.docx

Chapter 11-Oligonucleotide therapeutics-Prof. Yang.docx

Chapter 12-CRISPRCas9 a therapeutic solution by manipulating nucleic acids-prof.Deng.docx

chapter 13-Aptamer properties, functions and applications-prof Tan.docx

chapter 14-G-quadruplex as a platform for new perspectives in nucleic acid targeting for therapeutic applications-Prof.Sissi.doc