The Winter 2012 (vol. 14 no. 1) issue of the Nexus Network Journal is dedicated to the theme Architecture, Systems Research and Computational Sciences. This is an outgrowth of the session by the same name which took place during the eighth international, interdisciplinary conference Nexus 2010: Relationships between Architecture and Mathematics, held in Porto, Portugal, in June 2010. Today computer science is an integral part of even strictly historical investigations, such as those concerning the construction of vaults, where the computer is used to survey the existing building, analyse the data and draw the ideal solution. What the papers in this issue make especially evident is that information technology has had an impact at a much deeper level as well: architecture itself can now be considered as a manifestation of information and as a complex system. The issue is completed with other research papers, conference reports and book reviews.