This practical, well-organized reference delves deeply into functional group transformations, to provide all the detailed information that researchers need.Topics are organized into the following sections: oxidation, reduction, asymmetric synthesis, and functional group manipulationsEach section includes a description of the functional group transformation, the historical perspective, mechanisms, variations and improvements on the reaction, synthetic utilities and applications for the reaction, experimental details, and references to the primary literatureContributors are well-known and respected for their work on the specific name reactions.

Jie Jack Li is a medicinal chemist at Pfizer Global Research and Development in Ann Arbor, Michigan. He is coauthor ofContemporary Drug Synthesis and editor ofName Reactions in Heterocyclic Chemistry (both from Wiley).

E. J. Corey, Professor Emeritus at Harvard University, is scientific editorial advisor for this book. Dr. Corey won the Nobel Prize in Chemistry in 1990 for his development of the theory and methodology of organic synthesis, and was awarded the Priestley Medal in 2004.

Foreword vii

Preface viii

Contributing Authors ix

Chapter 1. Asymmetric Synthesis 1

Chapter 2. Reduction 85

Chapter 3. Oxidation 159

Chapter 4. Olefination 333

Chapter 5. Amine Synthesis 423

Chapter 6. Carboxylic Acid Derivatives Synthesis 457

Chapter 7. Miscellaneous Functional Group Manipulations 551

Appendixes 697

Appendix 1. Table of Contents for Volume 1:Name Reactions in Heterocyclic Chemistry 697

Appendix 2. Table of Contents for Volume 3:Name Reactions for Chain Extension 700

Appendix 3. Table of Contents for Volume 4:Name Reactions for Ring Formation 703

Appendix 4. Table of Contents for Volume 5:Name Reactions in Heterocyclic Chemistry-2 705

Subject Index 709