ATextbook of Biological Psychiatry integrates the basic science concerning brain mechanisms of psychiatric disorders alongside surveys of present standard clinical treatment. Organized in a coherent and easy to follow structure, chapters expand across different levels of analysis, from basic mechanisms to clinical practice. This comprehensive reference provides an integrative treatment of the biochemistry of neurotransmission, behavioral pharmacology, and clinical aspects of psychiatric problems including depression, manic-depression, and mood disorders. Other chapters address the biological mechanisms and treatment of depression, anxiety, panic, obsessive-compulsive disorder, and addictions. The editor concludes with a perspective on the future of the field and prospects for understanding and effectively treating mood and anxiety disorders.

Jaak Panksepp was an Estonian neuroscientist and psychobiologist who coined the term "affective neuroscience", the name for the field that studies the neural mechanisms of emotion.
J. P. Scott Center for Neuroscience, Mind and Behavior, Department of Psychology, Bowling Green State University, Bowling Green, Ohio and Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, Illinois and Adjunct Professor of Psychiatry, Medical College of Ohio, Toledo.

Foreword.

Preface.

Contributors.

Part I: FOUNDATIONAL CONCEPTS.

1. BIOLOGICAL PSYCHIATRY SKETCHED--PAST, PRESENT, AND FUTURE (Jaak Panksepp).

2. IMAGING HUMAN EMOTIONS AND AFFECTIVE FEELINGS: IMPLICATIONS FOR BIOLOGICAL PSYCHIATRY (Mario Liotti and Jaak Panksepp).

3. NEURAL SUBSTRATES OF CONSCIOUSNESS: IMPLICATIONS FOR CLINICAL PSYCHIATRY (Douglas F. Watt and David I. Pincus).

4. STRESS, SLEEP, AND SEXUALITY IN PSYCHIATRIC DISORDERS (Terrence Deak and Jaak Panksepp).

5. PSYCHOBIOLOGY OF PERSONALITY DISORDERS (Brian Knutson and Andreas Heinz).

6. FUNCTIONAL NEUROIMAGING IN PSYCHIATRY (Johannes Tauscher, Nikolas Klein, and Shitij Kapur).

Part II: CORE PSYCHIATRIC CHALLENGES.

7. DEPRESSION: A NEUROPSYCHIATRIC PERSPECTIVE (Helen S. Mayberg).

8. TREATMENT OF MOOD DISORDERS (Pedro L. Delgado and Paul Zarkowski).

9. NEUROSCIENCE OF SCHIZOPHRENIA (Christine Pesold, Rosalinda C. Roberts, and Brian Kirkpatrick).

10. PHARMACOLOGICAL TREATMENT OF SCHIZOPHRENIA (Rajiv Tandon and Michael D. Jibson).

11. PSYCHOBIOLOGY OF POSTTRAUMATIC STRESS DISORDER (Bessel A. van der Kolk).

12. NATURE AND TREATMENT OF PANIC DISORDER (Fredric N. Busch and Barbara L. Milrod).

13. NATURE AND TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER (Lisa A. Snider and Susan E. Swedo).

14. BIOLOGICAL BASIS OF CHILDHOOD NEUROPSYCHIATRIC DISORDERS (Bradley S. Peterson and Jaak Panksepp).

15. AGING AND DEMENTIA (Mark T. Wright, A. John McSweeny, and Amy Kieswetter).

Part III: FUTURE PROSPECTS.

16. EMERGING NEUROSCIENCE OF FEAR AND ANXIETY: THERAPEUTIC PRACTICE AND CLINICAL IMPLICATIONS (Jaak Panksepp).

17. SOMATIC TREATMENTS IN PSYCHIATRY (Ziad Nahas, Jeffrey P. Lorberbaum, Frank A. Kozel, and Mark S. George).

18. PSYCHOANALYSIS AND PSYCHOPHARMACOLOGY: ART AND SCIENCE OF COMBINING PARADIGMS (Marcia Kaplan).

19. DEPTH PSYCHOLOGICAL CONSEQUENCES OF BRAIN DAMAGE (Oliver H. Turnbull and Mark Solms).

20. SOCIOPHYSIOLOGY AND EVOLUTIONARY ASPECTS OF PSYCHIATRY (Russell Gardner, Jr. and Daniel R. Wilson).

21. FUTURE OF NEUROPEPTIDES IN BIOLOGICAL PSYCHIATRY AND EMOTIONAL PSYCHOPHARMACOLOGY: GOALS AND STRATEGIES (Jaak Panksepp and Jaanus Harro).

Appendix A: PHARMACODYNAMICS AND PHARMACOKINETICS (Jaanus Harro).

Index.