InhaltsangabeFOREWORD. INTRODUCTION. CONTRIBUTORS. PART I. COMPUTATIONAL AND STRUCTURAL APPROACHES IN DRUG DISCOVERY. CHAPTER 1. MOLECULAR DOCKING AND STRUCTURE-BASED DESIGN. CHAPTER 2. RECENT ADVANCES IN DRUG DISCOVERY RESEARCH USING STRUCTURE-BASED VIRTUAL SCREENING TECHNIQUES: EXAMPLES OF SUCCESS FOR DIVERSE PROTEIN TARGETS. CHAPTER 3. VIRTUAL SCREENING IN DRUG DISCOVERY. CHAPTER 4. COMPUTER-AIDED DRUG DESIGN. CHAPTER 5. FOCUSED LIBRARY DESIGN BASED ON HIT AND TARGET STRUCTURES: METHOD AND APPLICATION IN DRUG DISCOVERY. PART II. CHEMICAL AND SYNTHETIC APPROACHES IN DRUG DISCOVERY. CHAPTER 6. BEYOND NATURAL PRODUCTS: SYNTHETIC ANALOGUES OF BRYOSTATIN 1. CHAPTER 7. THE PROMISES AND PITFALLS OF SMALL-MOLECULE INHIBITION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG). CHAPTER 8. CYCLIC ADP-RIBOSE ANALOGUES WITH MINIMAL STRUCTURE: SYNTHESIS AND CALCIUM-RELEASE ACTIVITY. CHAPTER 9. EVALUATION OF NEUROIMMUNOPHILIN LIGANDS. CHAPTER 10. CHIRAL DRUGS AND THE ASSOCIATED ASYMMETRIC SYNTHESIS. CHAPTER 11. ALPHA-HELIX MIMETICS IN DRUG DISCOVERY 281 CHAPTER 12. BASIC AND TRANSLATIONAL RESEARCH OF CHEMOKINE LIGANDS AND RECEPTORS AND DEVELOPMENT OF NOVEL THERAPEUTICS. CHAPTER 13. RESEARCH PROGRESS IN PROTEIN POST-TRANSLATIONAL MODIFICATION. CHAPTER 14. CONTROLLED RELEASE OFANTIBIOTICS ENCAPSULATED IN NANOPOROUS SOL-GEL MATERIALS WITH TUNABLE PORE PARAMETERS. PART III. BIOLOGICAL APPROACHES AND TRANSLATIONAL RESEARCH IN DRUG DISCOVERY. CHAPTER 15. RETINOIC ACID AND ARSENIC TRIOXIDE TREATMENT IN ACUTE PROMYELOCYTIC LEUKEMIA: A MODEL OF ONCOPROTEIN TARGETED THERAPY. CHAPTER 16. 2-CHLORODEOXYADENOSINE. CHAPTER 17. APOPTOSIS-BASED DRUG DISCOVERY FOR CANCER. CHAPTER 18. MECHANISM-BASED DEVELOPMENT OF MEMANTINE AS A THERAPEUTIC AGENT IN TREATING ALZHEIMER'S DISEASE AND OTHER NEUROLOGIC DISORDERS: LOW-AFFINITY, UNCOMPETITIVE ANTAGONISM WITH FAST OFF-RATE. CHAPTER 19. BRIDGING BENCH TO CLINIC: ROLES OFANIMAL MODELS FOR POST-GENOMICS DRUG DISCOVERY ON METABOLIC DISEASES. CHAPTER 20. STEM CELL RESEARCH AND APPLICATIONS FOR HUMAN THERAPIES. INDEX.

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