While many clinicians currently recognize that bisphosphonate usage is associated with osteonecrosis of the jaws, this book establishes the causal relationship between the two, explaining the biologic modes of action that enable bisphosphonates taken both orally and intravenously to induce osteonecrosis of the jaws. Like the first edition, it presents definitive treatment protocols for patients who present at each stage in the progression of osteonecrosis, but this new edition also includes a simplified staging system and information about the serum CTX test for oral bisphosphonate cases. In addition, several management principles and surgical techniques are provided, along with new data on osteopenia and osteoporosis, the conditions for which bisphosphonates are primarily prescribed. The book offers a simple method for predicting risk as well as crucial recommendations for preventing the disease from developing when bisphosphonate therapy is indicated. Comprehensive case histories related to both oral and intravenous bisphosphonates provide direct guidance in managing patients spanning the full presentation spectrum. A must-have for the student and practicing clinician alike.

"Robert E. Marx, DDS, professor of surgery and chief of the Division of Oral and Maxillofacial Surgery, Miller School of Medicine, University of Miami, is a highly respected surgeon, researcher, and educator who has pioneered new concepts and treatments for pathologies of the oral and maxillofacial area as well as new techniques in major reconstructive surgery. He has made valuable contributions in the use of hyperbaric oxygen following radiation therapy; in the development of platelet-rich plasma; and in elucidating the relationship between smoking and carcinogenesis. For the past 30 years, he has trained scores of residents and fellows, many of whom have themselves established distinguished careers. He has published an impressive number of book chapters and journal articles; a textbook (with Diane Stern), Oral and Maxillofacial Pathology: A Rationale for Diagnosis and Treatment (Quintessence, 2003), which received the 2003 Award for Best Medical Book from the American Medical Writers Association; and a monograph (with Arun Garg), Dental and Craniofacial Applications of Platelet-Rich Plasma (Quintessence, 2005). He has received many other prestigious awards throughout his distinguished career as well, including the Harry S. Archer Award, the William J. Gies Award, the Paul Bert Award, and the Donald B. Osbon Award, all testaments to his dedication and commitment to the field of oral and maxillofacial surgery."

"1. Description and History of Bisphosphonate-Induced Osteonecrosis of the Jaws2. Modes of Action and Pharmacokinetics of the Bisphosphonate Family3. Medical Indications for Bisphosphonates4. Osteopetrosis: A Genetic Analogue to Bisphosphonate-Induced Osteonecrosis of the Jaws5. Risks, Prevention, and Management of Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws6. Risks, Prevention, and Management of Oral Bisphosphonate-Induced Osteonecrosis of the Jaws7. Clinical Pathologic Case Samples"