This book provides in-depth information about common clinical laboratory assays that are used to evaluate domestic mammals, including what assays measure, sample or assay conditions that affect results, and what results indicate about the physiologic or pathologic state of a patient. Whenever possible, diseases and conditions are grouped by common mechanisms or processes to promote a conceptual understanding of laboratory data that can be generally applied across many species. New to the second edition are additional disorders, diagnostic tests, illustrations, images, references, and pathophysiologic explanations. This text has proven valuable to students and veterinarians wanting a fundamental understanding of veterinary clinical pathology.

Steven L. Stockham, DVM, MS, Diplomate, American College of Veterinary Pathologists; Professor in the Department of Diagnostic Medicine/Pathobiology and Director of the Clinical Pathology Laboratory, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas.

Michael A. Scott, DVM, PhD, Diplomate, American College of Veterinary Pathologists, Assistant Professor in the Department of Pathobiology and Diagnostic Investigation and a Clinical Pathologist in the Diagnostic Center for Population and Animal Health, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.

Preface vii

Acknowledgments ix

1 Introductory Concepts 3

2 Leukocytes 53

3 Erythrocytes 107

4 Platelets 223

5 Hemostasis 259

6 Bone Marrow and Lymph Node 323

7 Proteins 369

8 Urinary System 415

9 Monovalent Electrolytes and Osmolality 495

10 Blood Gases, Blood pH, and Strong Ion Difference 559

11 Calcium, Phosphorus, Magnesium, and Their Regulatory Hormones 593

12 Enzymes 639

13 Liver Function 675

14 Glucose, Ketoamines, and Related Regulatory Hormones 707

15 Exocrine Pancreas and Intestine 739

16 Lipids 763

17 Thyroid Function 783

18 Adrenocortical Function 805

19 Cavitary Effusions 831

* Color plates between pages 494 and 495

Index 869