Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drugdrug interactions.

From a team of expert contributors,Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.

Amitava Dasgupta, Ph.D, DABCC, FACB, Professor of Pathology and Laboratory Medicine, University of Texas Health Sciences Center at Houston, Houston, TX.

Loralie J. Langman, Ph.D, DABCC, FACB, Associate Professor of Laboratory Medicine, Mayo Clinic, Rochester, MN.

Preface, ix

1 Pharmacogenomics Principles: Introduction to Personalized Medicine, 1
Parvaz Madadi, PhD and Gideon Koren, MD

2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? 15
Christine L.H. Snozek, PhD, Loralie J. Langman, PhD, and Amitava Dasgupta, Ph.D

3 Pharmacogenomics Aspect of Warfarin Therapy, 26
Matthew D. Krasowski, MD, PhD

4 Pharmacogenetics and Cancer Chemotherapy, 39
Christine L.H. Snozek

5 Pharmacogenomic Considerations in Anesthesia and Pain Management, 53
Christine M. Formea, PharmD and Wayne T. Nicholson, MD, PharmD

6 Pharmacogenomics of Immunosuppressants, 70
Nicolas Picard, PharmD, PhD and Pierre Marquet, MD, PhD

7 Pharmacogenomics of Cardiovascular Drugs, 98
Linnea M. Baudhuin, PhD

8 Pharmacogenomic Aspects of Antiretroviral Therapy, 127
Natella Y. Rakhmanina, MD, PhD and John N. van den Anker, MD, PhD

9 Pharmacogenetics of Psychoactive Drugs, 144
Jorge L. Sepulveda, MD, PhD

10 Pharmacogenomic Aspects of Adverse DrugDrug Interactions, 176
Loralie J. Langman, PhD and Christine L.H. Snozek, PhD

11 Microarray Technology and Other Methods in Pharmacogenomics Testing, 185
Jorge L. Sepulveda, MD, PhD

12 Pharmacogenetic Testing in the Clinical Laboratory Environment, 201
Mark P. Borgman, PhD and Mark W. Linder, PhD

Index, 225