Advances in DNA Repair in Cancer Therapy

Cancer Drug Discovery and Development

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Bibliografische Daten
ISBN/EAN: 9781461447405
Sprache: Englisch
Umfang: viii, 312 S.
Auflage: 1. Auflage 2013
Einband: gebundenes Buch

Beschreibung

InhaltsangabePreface.- Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs.- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy?.- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses.- The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy.- Important Roles of ERCC1 in DNA Repair and Targeted Therapy.- The role of BRCA1 and BRCA2 in anticancer drug therapy.- DNA-PK in CLL Chemotherapy.- Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair.- Cellular protection against the antitumor drug bleomycin.- ATR as a Therapeutic Target.- Telomeres, Telomerase and DNA Damage Response in Cancer Therapy.- RAD51 is a key protein of DNA repair and homologous recombination in humans.- Index.

Autorenportrait

InhaltsangabePreface.- Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs.- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy?.- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses.- The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy.- Important Roles of ERCC1 in DNA Repair and Targeted Therapy.- The role of BRCA1 and BRCA2 in anticancer drug therapy.- DNA-PK in CLL Chemotherapy.- Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair.- Cellular protection against the antitumor drug bleomycin.- ATR as a Therapeutic Target.- Telomeres, Telomerase and DNA Damage Response in Cancer Therapy.- RAD51 is a key protein of DNA repair and homologous recombination in humans.- Index.

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