InhaltsangabePreface.- The GW body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology.- The Discovery of GW Bodies.- The Discovery and Analysis of P Bodies.- Autoantibodies to Argonaute 2 (Su antigen).- GW/P Bodies and Autoimmune Disease.- Function of GW182 and GW Bodies in siRNA and miRNA Pathways.- Post-Transcriptional Stimulation of Gene Expression by MicroRNAs.- Gawky (Gw) is the Drosophila Melanogaster GW182 Homologue.- The Role of GW182 Proteins in miRNA-mediated Gene Silencing.- Quantifying Argonaute Proteins in and out of GW/P-bodies: Implications in microRNA Activities.- Deadenylation and P-bodies.- Relationship of GW/P-bodies with Stress Granules.- Relationship of other Cytoplasmic Ribonucleoprotein (RNP) Bodies to GW/P Bodies.- A SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182.- Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research.- Index.

InhaltsangabePreface.- Introduction.- The Discovery of GW Bodies and GW 182.- The Discovery of P Bodies.- Autoantibodies to Su/Ago2.- Autoantibodies to Ge-1 and other antigens associated with GW/P Bodies.- Function of GW 182 in RNAi.- miRNA and Translation Repression.- Gawky.- GW 182 and Translation Repression.- Ago2 and Translation Repression.- GW 182 Associated Complex.- Dcp-1 and Role in Assembly of P Bodies.- GW/P Bodies-Relationship to and Interaction with Stress Granules.- Relationship of Other Cellular RNP-containing bodies to GW/P Bodies.- GWBs and other LPS Response.- Conclusion.

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