In recent years it has become increasingly apparent that DNA repair processes play key roles in protecting genome integrity, where the failure of repair systems is directly responsible for many, if not the majority of, cancers. In DNA Damage and Repair, Vol. III: Advances from Phage to Humans, Jac A. Nickoloff and Merl F. Hoekstra update and expand their two earlier acclaimed volumes (Vol. I: DNA Repair in Prokaryotes and Lower Eukaryotes and Vol. II: DNA Repair in Higher Eukaryotes) with cutting-edge reviews by leading authorities of primary experimental findings about DNA repair processes in cancer biology. The reviews cover a wide range of topics from viruses and prokaryotes to higher eukaryotes, and include several new topics, among them the role of recombination in replication of damaged DNA, X-ray crystallographic analysis of DNA repair protein structures, DNA repair proteins and teleomere function, and the roles of BRCA1 and BRCA2 in DNA repair. The contributors make every effort to integrate the basic experimental information with clinical aspects of cancer biology as they relate to DNA repair. Authoritative and up-to-date, DNA Damage and Repair, Vol. III: Advances from Phage to Humans surveys the rapidly moving research in DNA damage and repair, offering broad integrated coverage that will help researchers understand the important functional relationships among different DNA repair pathways, as well as the relationships among DNA repair pathways, cancer etiology, and cancer therapies.

InhaltsangabeDNA Repair in Bacteriophage, Carol Bernstein and Harris Bernstein. Post-Replication Repair: A New Perspective Focusing on the Coordination Between Recombination and DNA Replication, Steven J. Sandler. A basic Site Repair in Higher Eukaryotes, Phyllis R. Strauss and Noreen E. O'Regan. Structure and Functions of the Major Human AP Endonuclease HAP1/Ref-1, Ian D. Hickson, Michael A. Gorman, and Paul S. Freemont. Mating-Type Control of DNA Repair and Recombination in Saccharomyces cerevisiae, Jac A. Nickoloff and James E. Haber. DNA End-Processing and Heteroduplex DNA Formation During Recombinational Repair of DNA Double-Strand Breaks, Galina Petukhova, Eva Y.-H. P. Lee, and Patrick Sung. The MRE11-RAD50 Complex: Diverse Functions in the Cellular DNA Damage Response, John H. J. Petrini, Richard S. Maser, and Debra A. Bressan. Repair of DNA Double-Strand Breaks and Mismatches in Drosophila, Carlos C. Flores. Double-Strand Break Repair and Homologous Recombination in Mammalian Cells, Maria Jasin. BRCA1 and BRCA2 in DNA Repair and Genome Stability, Mark A. Brenneman. DNA Repair and the Generation of Immune Diversity: The Agony and the Ecstasy, Lauryl M. J. Nutter, Chrystal K. Palaty, Martin Nemec, Cynthia J. Guidos, and Jayne S. Danska. Interaction of Cell-Cycle Checkpoints with Muscle Differentiation, Troy Fiddler, Jing Huang, Elizabeth Ostermeyer, Teresa Johnson-Pais, and Mathew J. Thayer. Ultraviolet Light-Induced and Spontaneous Recombination in Eukaryotes: Roles of DNA Damage and DNA Repair Proteins, Colin A. Bill and Jac A. Nickoloff. Telomeres, DNA Repair Proteins, and Making Ends Meet, Susan M. Bailey, Julianne Meyne, and Edwin H. Goodwin. Conservation of Eukaryotic DNA Repair Mechanisms, Alan R. Lehmann and Elaine M. Taylor. Index.