The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells.

InMyeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including

the recruitment of myeloid and other immune cells following microbial infectionthe role of myeloid cells in the inflammation process and the repair of damaged tissuethe vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforinreceptors and downstream signaling pathways that are activated following ligand-receptor bindingroles of myeloid cells during microbial and parasite infectionscontributions of myeloid cells in atherosclerosismyeloid-derived suppressor cells in tumor development and cancer

Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.

Contributors

Preface

Acknowledgments

About the Editor

Section I Introduction and History

1 Paul Ehrlich and the Early History of Granulocytes
A. Barry Kay

2 The Phagocyte, Metchnikoff, and the Foundation of Immunology
Giuseppe Teti, Carmelo Biondo, and Concetta Beninati

3 Growth and Differentiation Factors
Donald Metcalf and Nicos A. Nicola

Section II General Aspects

4 Evolution of Myeloid Cells
Daniel R. Barreda, Harold R. Neely, and Martin F. Flajnik

5 Advances on Myeloid Like-Cell Origins and Functions in the Model Organism Drosophila melanogaster
Laure El Chamy, Nicolas Matt, and Jean-Marc Reichhart

6 Monocyte, Macrophage, and Dendritic Cell Development: the Human Perspective
Matthew Collin and Venetia Bigley

7 Myeloid Cell Turnover and Clearance
William J. Janssen, Donna L. Bratton, Claudia V. Jakubzick, and Peter M. Henson

Section III Specialization

8 Transcriptional Regulation and Macrophage Differentiation
David A. Hume, Kim M. Summers, and Michael Rehli

9 Murine Monocytes: Origins, Subsets, Fates, and Functions
Alexander Mildner, Goran Marinkovic, and Steffen Jung

10 Dendritic Cells in the Immune SystemHistory, Lineages, Tissues, Tolerance, and Immunity
Jonathan M. Austyn

11 Antigen Processing and Presentation Mechanisms in Myeloid Cells
Paul A. Roche and Peter Cresswell

12 Microglia
V. Hugh Perry

13 OsteoclastsKey Players in Skeletal Health and Disease
Deborah Veis Novack and Gabriel Mbalaviele

14 The Regulatory Function of Eosinophils
Ting Wen and Marc E. Rothenberg

Section IV Recruitment, Inflammation, and Repair

15 Intravital Imaging of Myeloid Cells: Inflammatory Migration and Resident Patrolling
Justin F. Deniset and Paul Kubes

16 Multifaceted Functions of NOD-Like Receptor Proteins in Myeloid Cells at the Intersection of Innate and Adaptive Immunity
Thomas A. Kufer, Giulia Nigro, and Philippe J. Sansonetti

17 Inflammasomes in Myeloid Cells: Warriors Within
Sushmita Jha and Jenny Pan-Yun Ting

18 Inflammationa Critical Appreciation of the Role of Myeloid Cells
Asif J. Iqbal, Edward A. Fisher, and David R. Greaves

19 Lipid Mediators in Inflammation
Melanie Bennett and Derek W. Gilroy

20 Macrophage Proresolving Mediatorsthe When and Where
Jesmond Dalli and Charles Serhan

21 Myeloid Cells in Cutaneous Wound Repair
Jenna L. Cash and Paul Martin

Section V Recognition, Signaling, and Gene Expression

22 The Role and Function of Fc Receptors on Myeloid Cells
Stylianos Bournazos, Taia T. Wang, and Jeffrey V. Ravetch

23 Complement Receptors in Myeloid Cell Adhesion and Phagocytosis
Michael L. Dustin

24 Toll-Like Receptor Signaling and Its Inducible Proteins
Takashi Satoh and Shizuo Akira

25 Lectin Receptors Expressed on Myeloid Cells
Gordon D. Brown and Paul R. Crocker

26 G Protein-Coupled Receptors in Macrophages
Hsi-Hsien Lin and Martin Stacey

27 Molecular Mechanisms of Phagosome Formation
Valentin Jaumouillé and Sergio Grinstein

28 Role of the Cytoskeleton in Myeloid Cell Function
Noah Fine, Samira Khaliq, Siavash Hassanpour, and Michael Glogauer

29 Coordinated Regulation of Signaling Pathways during Macrophage Activation
Toby Lawrence

30 Genome-Wide Approaches to Defining Macrophage Identity and Function
Gregory J. Fonseca, Jason S. Seidman, and Christopher K. Glass

31 Epigenetic Regulation of Myeloid Cells
Lionel B. Ivashkiv and Sung Ho Park

Section VI Secretion and Defense

32 Secretion from Myeloid Cells: Secretory Lysosomes
Gillian M. Griffiths

33 The NADPH Oxidase and Microbial Killing by Neutrophils, With a Particular Emphasis on the Proposed Antimicrobial Role of Myeloperoxidase within the Phagocytic Vacuole
Adam P. Levine and Anthony W. Segal

34 Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells
Ryan G. Gaudet, Clinton J. Bradfield, and John D. MacMicking

35 Anti-TNF Therapy
Irina Udalova, Claudia Monaco, Jagdeep Nanchahal, and Marc Feldmann

36 Metalloproteinases: a Functional Pathway for Myeloid Cells
Jonathan Chou, Matilda F. Chan, and Zena Werb

Section VII Immunoregulation and Infection

37 Interplay between Myeloid Cells and Humoral Innate Immunity
Sébastien Jaillon, Eduardo Bonavita, Cecilia Garlanda, and Alberto Mantovani

38 Adaptive Characteristics of Innate Immune Responses in Macrophages
Rob J. W. Arts and Mihai G. Netea

39 Intestinal Mononuclear Phagocytes in Health and Disease
Theodore J. Sanders, Ulf Yrlid, and Kevin J. Maloy

40 Strategies Used by Bacteria to Grow in Macrophages
Gabriel Mitchell, Chen Chen, and Daniel A. Portnoy

41 Mechanisms of Defense against Intracellular Pathogens Mediated by Human Macrophages
Barry R. Bloom and Robert L. Modlin

42 Myeloid Cells in Asthma
Bart N. Lambrecht, Emma Persson, and Hamida Hammad

43 Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections
Rick M. Maizels and James P. Hewitson

44 Induction of Immunological Tolerance as a Therapeutic Procedure
Herman Waldmann, Duncan Howie, and Stephen Cobbold

Section VIII Metabolic and Malignant Disease

45 Glutathione and Glutathione Transferase Omega 1 as Key Post-Translational Regulators in Macrophages
Mark M. Hughes, Anne F. McGettrick, and Luke A.J. ONeill

46 Macrophages and Iron Metabolism
Tomas Ganz

47 Mechanisms of Myeloid Cell Modulation of Atherosclerosis
Filip K. Swirski, Matthias Nahrendorf, and Peter Libby

48 Macrophages in Endocrine Glands with Emphasis on Pancreatic Islets
Emil R. Unanue

59 Tumor-Induced Myeloid-Derived Suppressor Cells
Francesco De Sanctis, Vincenzo Bronte, and Stefano Ugel

50 Myeloid Cell Origins, Differentiation, and Clinical Implications
Kipp Weiskopf, Peter J. Schnorr, Wendy W. Pang, Mark P. Chao, Akanksha Chhabra, Jun Seita,Mingye Feng, and Irving L. Weissman

Index