Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers. The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth. Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.

InhaltsangabeProstate Cancer: Novel Biology, Genetics and Therapy Part I Preface - to be submitted The Lance Armstrong Effect: Turning up the Heat to Cure Other Advanced Cancers Dr. Donald S. Coffey Part II Biology and Imaging 1. Xenograft Models of Human Prostate Cancer Drs. Robert Vessella and Eva Corey 2. The Pathology of Human Prostatic Atrophy and Inflammation Dr. Angelo DeMarzo 3. Tissue Microarrays in Prostate Cancer Research Drs. Milton Datta and André A. Kajdacsy-Balla 4. Prostate (Cancer) Stem Cells Dr. Jack Schalken 5. Cancerhost interactions: A paradigm shift brings new understanding and new opportunities Dr. Leland W. K. Chung, Dr. Wen-Chin Huang, Dr. Shian-Ying Sung, Dr. Daqing Wu, Dr. Valerie Odero-Marah, and Dr. Haiyen E. Zhau 6. Androgen Receptor Function in Prostate Cancer Progression Drs. Helmut Klocker, Iris E. Eder, Barbara Comuzzi, Georg Bartsch and Zoran Culig 7. Hedgehog Signaling in Development and Cancer Dr. Wade Bushman 8. Cholesterol, Cell Signaling and Prostate Cancer Drs. Mohini Lutchman, Keith R. Solomon, and Michael R. Freeman 9. Gene Therapy for Advanced Prostate Cancer Juan Antonio Jiménez, Xiong Li, MD, PhD, Thomas A. Gardner, MD, and Chinghai Kao, PhD 10. Role of Transforming Growth Factor-b in Immunotherapy of Prostate Cancer Drs. Chung Lee, Ali Shah, Victoria Liu, Irwin Park, Larry Wong, Xuemei Huang, Lijun Huang, Tim Fermin, Tom Jang, Som Kundu, Vivian Zhou, Qiang Zhang, Norm Smith 11. Biology and Therapeutic Basis of Prostate Cancer Bone Metastasis Dr. Evan Keller 12. Molecular Imaging: Noninvasive Strategies to Visualize Gene Expression in Living Subjects Drs. Meera Iyer and Sanjiv S. Gambhir 13. Quantum Dot Nanotechnology for Prostate Cancer Research Drs. Xiaohu Gao, Yun Xing, Leland C. W. Chung, and Shuming Nie Part IIIGenetics 14. Expression Profiling of Prostate Cancer Progression Drs. Scott A. Tomlins, Arul M. Chinnaiyan 15. Somatic Alterations in Prostate Cancer Progression Drs. Kati P. Porkka and Tapio Visakorpi 16. Linkage Studies of Prostate Cancer Families to Identify Susceptibility Genes Drs. Bill Isaacs and Jianfeng Xu 17. Somatic DNA Methylation Changes and Prostatic Carcinogenesis Drs. William G. Nelson, Srinivasan Yegnasubramanian, Patrick J. Bastian, Masashi Nakayama, and Angelo M. De Marzo 18. Telomeres, Telomerase, Chromosome Stability and Prostate Cancer Dr. Alan Meeker Part IV Therapeutics 19. Racial Differences in Prostate Cancer Mortality Dr. James Mohler 20. Radiotherapy for the Treatment of Locally Advanced Prostate Cancer Dr. Theodore DeWeese and Danny Song 21. Recombinant Antibody Candidates for Treatment of Prostate Cancer Drs. Anoop M. Meraney and Warren W.D. Heston 22. Differentiation Agents and Epigenomics Therapies: An Overview and Potential Use for Prostate Cancer Drs. Madeleine S. Q. Kortenhorst, Michael A. Carducci, Shabana Shabbeer 23. Taxanebased Chemotherapy for Prostate Cancer Drs. Supriya G. Mohile and Daniel Petrylak 24. CoTargeting Therapeutics for Hormone Refractory Prostate Cancer Dr. Vassily Assikis 25. New Intercellular Targets Lethal Phenotypes of Prostate Cancer Drs. Daniel George and Young E. Whang 26. Novel and Efficient Translational Clinical Trials Designs in Advanced Prostate Cancer Drs. André Rogatko and Mourad Tighiouart