Inhaltsangabe1. Introduction to Viral Vectors            James N. Warnock, Claire Daigre, and Mohamed Al-Rubeai 2. Introduction to Gene Therapy: A Clinical Aftermath            Patrice P. Denèfle 3. Host Cells and Cell Banking            Glyn N. Stacey and Otto-Wilhelm Merten 4. Overview of Current Scalable Methods for Purification of Viral Vectors            María Mercedes Segura, Amine Kamen, and Alain Garnier 5. Methods to Construct Recombinant Adenovirus Vectors            Miguel Chillon and Ramon Alemany 6. Manufacturing of Adenoviruses Vectors: Production and Purification of Helper Dependent Adenovirus            Edwige Dormond and Amine A. Kamen 7. Manufacturing of Retroviruses            Pedro E. Cruz, Teresa Rodrigues, Marlene Carmo, Dagmar Wirth, Ana Amaral, Paula M. Alves, and Ana S. Coroadinha 8. Lentiviral Vectors            Marc Giry-Laterrière, Els Verhoeyen, and Patrick Salmon 9. Adeno-Associated Viruses            Mauro Mezzina and Otto-Wilhelm Merten 10. Manufacturing of Adeno-Associated Viruses, for Example: AAV2            Haifeng Chen 11. Vector Characterization Methods for Quality Control Testing of Recombinant Adeno-Associated Viruses            J. Fraser Wright and Olga Zelenaia 12. Baculoviruses Mediate Efficient Gene Expression in a Wide Range of Vertebrate Cells            Kari J. Airenne, Kaisa-Emilia Makkonen, Anssi J. Mähönen, and Seppo Ylä-Herttuala 13. Herpes Simplex Virus Type 1 (HSV-1)-Derived Recombinant and Amplicon Vectors            Cornel Fraefel, Peggy Marconi, and Alberto L. Epstein 14. Manufacture of Measles Viruses            Kirsten K. Langfield, Henry J. Walker, Linda C. Gregory, and Mark J. Federspiel 15. In Vivo Gene Delivery into hCD34+ Cells in a Humanized Mouse Model            Cecilia Frecha, Floriane Fusil, François-Loïc Cosset, and Els Verhoeyen 16. In Vivo Evaluation of Gene Transfer into Mesenchymal Cells (in View of Cartilage Repair)            Kolja Gelse and Holm Schneider 17. Ethical Consideration            Michael Fuchs 18. Clinical Trials of GMP Products in the Gene Therapy Field            Kathleen B. Bamford

1. Introduction to Viral Vectors             James N. Warnock, Claire Daigre, and Mohamed Al-Rubeai   2. Introduction to Gene Therapy: A Clinical Aftermath             Patrice P. Denefle   3. Host Cells and Cell Banking             Glyn N. Stacey and Otto-Wilhelm Merten   4. Overview of Current Scalable Methods for Purification of Viral Vectors             María Mercedes Segura, Amine Kamen, and Alain Garnier   5. Methods to Construct Recombinant Adenovirus Vectors             Miguel Chillon and Ramon Alemany   6. Manufacturing of Adenoviruses Vectors: Production and Purification of Helper Dependent Adenovirus             Edwige Dormond and Amine A. Kamen   7. Manufacturing of Retroviruses             Pedro E. Cruz, Teresa Rodrigues, Marlene Carmo, Dagmar Wirth, Ana Amaral, Paula M. Alves, and Ana S. Coroadinha   8. Lentiviral Vectors             Marc Giry-Laterriere, Els Verhoeyen, and Patrick Salmon   9. Adeno-Associated Viruses             Mauro Mezzina and Otto-Wilhelm Merten   10. Manufacturing of Adeno-Associated Viruses, for Example: AAV2             Haifeng Chen   11. Vector Characterization Methods for Quality Control Testing of Recombinant Adeno-Associated Viruses             J. Fraser Wright and Olga Zelenaia   12. Baculoviruses Mediate Efficient Gene Expression in a Wide Range of Vertebrate Cells             Kari J. Airenne, Kaisa-Emilia Makkonen, Anssi J. Mähönen, and Seppo Ylä-Herttuala   13. Herpes Simplex Virus Type 1 (HSV-1)-Derived Recombinant and Amplicon Vectors             Cornel Fraefel, Peggy Marconi, and Alberto L. Epstein   14. Manufacture of Measles Viruses             Kirsten K. Langfield, Henry J. Walker, Linda C. Gregory, and Mark J. Federspiel   15. In Vivo Gene Delivery into hCD34+ Cells in a Humanized Mouse Model             Cecilia Frecha, Floriane Fusil, Francois-Loïc Cosset, and Els Verhoeyen   16. In Vivo Evaluation of Gene Transfer into Mesenchymal Cells (in View of Cartilage Repair)             Kolja Gelse and Holm Schneider   17. Ethical Consideration             Michael Fuchs   18. Clinical Trials of GMP Products in the Gene Therapy Field             Kathleen B. Bamford