Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. Homology modeling is an in silico method that predicts the tertiary structure of an amino acid sequence based on a homologous experimentally determined structure.  In, Homology Modelling: Methods and Protocols experts in the field describe each homology modeling step from first principles, provide case studies for challenging modeling targets and describe methods for the prediction of how other molecules such as drugs can interact with the protein. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Homology Modelling: Methods and Protocols guides scientists in the available homology modeling methods. 

Inhaltsangabe1. Classification of Proteins: Available Structural Space for Molecular ModellingAntonina Andreeva2. Effective Techniques for Protein Structure MiningStefan J. Suhrer, Markus Gruber, Markus Wiederstein, Manfred J. Sippl 3. Methods for Sequence-Structure AlignmentCeslovas Venclovas4. Force Fileds for Homology Modeling Andrew J. Bordner5. Automated Protein Structure Modeling with SWISS-MODELWorkspace and the Protein Model PortalLorenza Bordoli and Torsten Schwede6. A Practical Introduction to Molecular Dynamics Simulations: Applications to Homology ModelingAlessandra Nurisso, Antoine Daina and Ross C. Walker7. Methods for Accurate Homology Modeling by Global OptimizationKeehyoung Joo, Jinwoo Lee, Jooyoung Lee8. Ligand- Guided Receptor Optimization Vsevolod Katritch, Manuel Rueda, Ruben Abagyan9. Loop Simulations Maxim Totrov10. Methods of Protein Structure Comparison Irina Kufareva and Ruben Abagyan11. Homology Modeling of Class A G Protein-Coupled ReceptorsStefano Costanzi12. Homology Modeling of Transporter Proteins (Carriers and Ion Channels) Aina Westrheim Ravna and Ingebrigy Sylte13. Methods for the Homology Modeling of Antibody Variable RegionsAroop Sircar14. Investigation Protein Variants using Structural Calculation TechniquesJonas Carlsson and Bengt Persson15. Macromolecular Assembly Structures by Comparative Modeling and Electron MicroscopyKeren Lasker, Javier A. Velázquez-Muriel, Benjamin M. Webb, Zheng Yang, Thomas E. Ferrin, and Andrej Sali16. Preparation and Refinement of Model Protein-Ligand ComplexesAndrew J.W. Orry  and Ruben Abagyan 17. Modeling Peptide-protein InteractionsNir London, Barak Raveh, Ora Schueler-Furman18. Comparison of Common Homology Modeling Algorithms: Applications of User-defined Alignments Michael A. Dolan, James W. Noah, and Darrell Hurt