Revenge of the MicrobesWhat is antibiotic resistance, and why should I care?
Two decades after the first edition ofRevenge of the Microbes: How Bacterial Resistance Is Undermining the Antibiotic Miraclewarned of the looming threat of antibiotic resistance, it is now upon us. Not only has the spread of antibiotic resistance continued unabated, but the emergence of multidrug-resistant superbugs is poised to set medical progress back centuries. Several distinct biological, social, economic, and technological factors have resulted in us only barely keeping pace with these new threats.
In this edition ofRevenge of the Microbes,the authors detail the intricacies of the antibiotic-microbe arms race. Beginning with a historical perspective on antibiotics and their profound impact on both modern medicine and present-day society, they review our current arsenal against infectious diseases and the various ways pathogens evade or overcome them. The authors examine the practices and policies driving the discovery and development of new antibiotics, what happens to antibiotics once they are released into the environment, how antibiotic-resistant bacteria evolve and spread, and the urgency for finding alternative approaches to combating infections. This discussion of the controversies surrounding antibiotics will empower readerscitizen scientists, policy makers, pharmaceutical researchers, and medical professionals aliketo generate informed opinions on antibiotic usage and stewardship as we contend with fewer effective antibiotics.
Reader-friendly and comprehensible, this new edition ofRevenge of the Microbesengages a diverse audience of scientists, clinicians, educators, students, lawyers, environmentalists, and public health advocates as it explores the ever-changing landscape of the antibiotic resistance crisis.
For anyone interested in antimicrobial resistance (AMR), this is a completely approachable 360-degree view of a very complex topic. The authors dont dilute the science but manage to deliver it in language and examples that everyone can digest. Dont miss the Points to Ponder at the end of each chapter. These thought-provoking nuggets will inspire creative thinking even in the most experienced AMR authorities.
JEAN B. PATEL, PhD, D(ABMM),Principle Scientist, Scientific Affairs, Microbiology, Beckman Coulter; former Science Team Lead, Antibiotic Resistance Coordination and Strategy Unit, CDC
Foreword byStanley Maloy ix
Preface xiii
About the Authors xv
Chapter 1 Antibiotics: What Are They? 1
Chapter 2 The Miracle in Miracle Drugs 11
Chapter 3 Bacterial Resistance Threatens the Mighty Reign of Antibiotics 27
Chapter 4 A Brief Look at the History of Antibiotics 41
Chapter 5 Bacterial Targets of Antibiotics: How Antibiotics Work 49
Chapter 6 Bacteria Reveal Their Adaptability and Gain Resistance 71
Chapter 7 The Spread of Antibiotic Resistance 85
Chapter 8 The Escalating Crisis in Antibiotic Availability Amidst Renewed Efforts 107
Chapter 9 The Battle Continues To Combat Antibiotic Resistance: Alternative Approaches 127
Chapter 10 Building a Viable Framework for Tackling the Escalating Antibiotic Resistance Crisis 139
Index 153
