<p><fontcolor="red"><strong><em>Covering all state-of-the-art experimental research methods in orthopedic surgery and trauma</em></strong></font></p><p>From bioinformatics to nanotechnology, advances in basic research ultimately drive advances in clinical care. This book provides a comprehensive summary of all current research methodologies for translational and pre-clinical studies in biomechanics and orthopedic trauma surgery. With this "roadmap" at hand, specialists and trainees will have the tools to conduct high-quality experimental research in any area of musculoskeletal science, with a solid understanding of how the findings can be applied in patient care.</p><p>Special Features:</p><ul><li>Utilizes the principles and methodology of modern, evidence-based medicine in pre-clinical musculoskeletal research<li> Offers a comprehensive analysis of in vivo models for studying different components of the musculoskeletal system<li> Demonstrates how principles of structural, functional, and numerical biomechanics can be utilized in well-defined experimental research studies– spanning topics from fracture fixation to gait analysis to bone remodeling<li> Covers the role of new macroscopic CT and ultrasound imaging techniques for assessing bone and cartilage function<li> Explores cutting-edge developments in cell culture research, molecular testing, and tissue engineering<li> Provides practical advice, a glossary of key terminology, and hundreds of illustrations to familiarize clinicians with every aspect of designing and interpreting an effective research study</li></ul><p>With 54 state-of-the-art chapters by orthopedic surgeons, musculoskeletal physicians, biologists, engineers, physicists, and mathematicians,<em>Experimental Research Methods in Orthopedics and Trauma</em> is the authoritative reference on the topic. It is essential for clinicians, basic researchers, and orthopedic surgical trainees who need to understand experimental research methodology

<p><strong>Part 1 Why Do We Need Experimental Research?</strong><br>1 Evidence-Based Research<br>2 Establishing a Basic Research Facility in Orthopedic Surgery<br>3 Good Laboratory Practice and Quality Control<br>4 How to Prepare for a Period in Research<br><strong>Part 2 Structural Biomechanics</strong><br>5 Physiological Boundary Conditions for Mechanical Testing<br>6 Static, Dynamic, and Fatigue Mechanical Testing<br>7 Use of Human and Animal Specimens in Biomechanical Testing<br>8 Whole Bone Biomechanics<br>9 Biomechanics of Trabecular and Cortical Bone<br>10 Biomechanics of Fracture Fixation<br>11 Biomechanical Assessment of Fracture Repair<br>12 Biomechanics of Cartilage<br>13 Biomechanics of Joints<br>14 Spine Biomechanics<br><strong>Part 3 Functional Biomechanics</strong><br>15 Musculokeletal Dynamics<br>16 Measurement Techniques<br>17 Clinical Assessment of Function<br>18 Functional Biomechanics with Cadaver Specimens<br><strong>Part 4 Numerical Biomechanics</strong><br>19 Inverse Dynamics<br>20 Principles of Finite Elements Analysis<br>21 Validation of Finite Element Models<br>22 Computational Biomechanics of Bone<br>23 Numerical Simulation of Implants and Prosthetic Devices<br>24 Numerical Simulation of Fracture Healing and Bone Remodelling<br><strong>Part 5 Imaging</strong><br>25 Micro-Computed Tomography Imaging of Bone Tissue<br>26 Imaging Bone<br>27 Ultrasound Techniques for Imaging Bone<br>28 In Vivo Scanning<br>29 Imaging of Cartilage Function<br>30 Histochemistry Bone and Cartilage<br>31 Immunohistochemistry<br>32 Molecular Imaging In Situ Hybridization<br>33 Laser Scanning Confocal Microscopy and Laser Microdissection<br>34 Image Analysis Histomorphometry Stereology<br><strong>Part 6 Cellular Studies</strong><br>35 Cell Culture Research<br>36 Cartilage Explants and Organ Culture Models<br>37 Fluid Flow and Strain in Bone<br>38 Biomechanics of Bone Cells<br><strong>Part 7 Molecular Techniques in Bone Repair</strong><br>39 Molecular Testing<br>40 Genetically Modified Models for Bone Repair<br><strong>Part 8 In Vivo Models</strong><br>41 General Considerations for an In Vivo Model<br>42 Animal Models for Bone Healing<br>43 Models for Impaired Healing<br>44 In Vivo Models for Bone and Joint Infections<br>45 In Vivo Models for Articular Cartilage Repair<br>46 In Vivo Soft Tissue Models<br><strong>Part 9 Tissue Engineering</strong><br>47 Scaffolds for Tissue Engineering and Materials for Repair<br>48 Use of Growth Factors in Musculoskeletal Research<br>49 Stem Cells for Musculoskeletal Repair<br>50 Biological Evaluation and Testing of Medical Devices<br><strong>Part 10 Statistics for Experimental Research</strong><br>51 Study Design<br>52 Power and Sample Size Calculation<br>53 Nonparametric versus Parametric Tests<br>54 How to Limit Bias in Experimental Research</p>