Anserine, a naturally histidine dipeptide, has a remarkable radio and hepatoprotective effect against gamma radiation-induced hepatotoxicity and may be other types of hepatotoxicities. Also zinc has proved to have a potentiating effect along with anserine and this confirm its hepatoprotective and antioxidant effects. It is better to recommend a collective combination of anserine and zinc in treatment of as well as protection against radiation induced or other types of hepatotoxicities. Hence we encourage further investigation on anserine and anserine related compounds with other trace elements having antioxidant or hepatoprotective effect to find a better combination that gives the best prophylactic or curative effect against gamma radiation-induced hepatotoxicity.

Sanaa Ahmed Ali, M.Sc and Ph.D Faculty of science, Ain Shams University. Professor of Biochemistry Theraputic Chemistry Department National Research Centre; Laila M.Faddah Professor of Pharmacology,Dep.of Pharmacology,Faculty of Pharmacy King Saud University; Maiiada Hassan Nazmy Lecturer of Biochemistry,Faculty of Pharmacy El-Minia University.

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