Actinidic archaea has been related to human diseases especially multinodular goitre, chronic calcific pancreatitis, endomyocardial fibrosis and mucoid angiopathy. The growth of endosymbiotic actinidic archaea leads to neanderthalisation of the human mind-body system. Neanderthal metabolonomics has been described in these disorders especially the Warburg phenotype and hyperdigoxinemia. Digoxin produced by archaeal cholesterol catabolism produces neanderthalisation. Prefrontal cortical atrophy and cerebellar hyperplasia has been related to these disorders. This leads on to dysautonomia with sympathetic hyperactivity and parasympathetic neuropathy in these disorders. A method to modulate archaeal symbiosis and interconverting homo sapien to homo neanderthalis and vice versa is described. This is done by a high fibre versus a low fibre diet, administration of antioxidant antibiotic and colonic microflora from human and cow dung. This can be called as a therapeutic archaeal symbiotic modulated human evolution for the treatment of multinodular goitre, chronic calcific pancreatitis, endomyocardial fibrosis and mucoid angiopathy.

Dr Ravikumar Kurup is the Director of the Metabolic Disorders Research Centre, Trivandrum. His areas of interest are Metabolic Medicine and Symbiotic Biology.