Exploring novel classes of antitumor agents is an excellent approach to treat cancer diseases, which is responsible for major deaths worldwide. Pyrazolo[1,5-a]pyrimidine derivatives occupy a unique place in medicinal chemistry due to its various pharmacological activities. Besides, pyrazolo[1,5-a]pyrimidine derivatives are purine analogue of particular significance in medicinal chemistry due to their broad scope of remarkable antitumor activities. In this context, a new series of pyrazolo[1,5-a]pyrimidine derivatives were synthesized, characterized by their spectral data and screened for their antitumor activities.

Dr. Ashraf Sayed Hassan and Dr. Nesrin Mahmoud Morsy Mohamed are an Associate Professors and Dr.Taghrid Shoukry Mohamed Hafez is an Emeritus Professor. They are working at Organometallic and Organometalloid Chemistry Department, Chemical Industries Research Division, National Research Centre, Cairo, Egypt. They are interested in Organic Chemistry.

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