The neglected tropical diseases (NTDs) are among the most common infections of the worlds poorest people and have profound ramifications on affected populations, including physical, mental, social, and economic. This third edition ofForgotten People, Forgotten Diseases coincides with the third decade of the NTDs movement, which has given access to essential NTD preventative treatments and medications to more than 1 billion people.

Professor Peter Hotez, MD, PhD, one of the founders of the NTD movement, discusses how the NTD space evolved and control was implemented against these ancient scourges, through alliances between nongovernmental development organizations and private-public partnerships.Forgotten People, Forgotten Diseases also

Forgotten People, Forgotten Diseases remains an essential resource for anyone seeking insight into global advocacy coordination and mobilization of resources to combat NTDs and continues to tell the story of the worlds people who live in extreme poverty and what it means for them to live with these devastating diseases.

Like Dr. Hotez, I have struggled with how to best get the word out about our need to address NTDs and their link to poverty. Now he has provided us all with a remarkable tool, a book for people without an extensive scientific or medical background.Forgotten People, Forgotten Diseases is an excellent one-stop primer about NTDs.Soledad OBrien, Host, Matter of Fact with Soledad OBrien

Peter J. Hotez, MD, PhD, is an internationally-recognized physician-scientist in NTDs and vaccine development. Professor Hotez is Dean of the National School of Tropical Medicine and Professor of Pediatrics and Molecular Virology& Microbiology at Baylor College of Medicine, codirector of the Texas Childrens Center for Vaccine Development, Texas Childrens Hospital Endowed Chair of Tropical Pediatrics, and the founding Editorin-Chief ofPLoS Neglected Tropical Diseases, among other appointments.

Like Dr. Hotez, I have struggled with how to best get the word out about our need to address NTDs and their link to poverty. Now he has provided us all with a remarkable tool, a book for people without an extensive scientific or medical background.Forgotten People, Forgotten Diseasesis an excellent one-stop primer about NTDs.

Soledad OBrien, Host,Matter of Fact with Soledad OBrien

Preface ix

Acknowledgments xiii

Chapter 1 Introduction to the Neglected Tropical Diseases: the Ancient Afflictions of Stigma and Poverty 1

Chapter 2 The Unholy Trinity: the Soil-Transmitted Helminth Infections Ascariasis, Trichuriasis, and Hookworm Infection 17

Chapter 3 Schistosomiasis (Snail Fever) and the Food-borne Trematodiases 39

Chapter 4 Elephantiasis: Lymphatic Filariasis, Endemic Nonfilarial Elephantiasis (Podoconiosis), and Dracunculiasis (Guinea Worm) 55

Chapter 5 The Blinding Neglected Tropical Diseases: Onchocerciasis (River Blindness) and Trachoma 75

Chapter 6 The Mycobacterial Infections: Buruli Ulcer and Leprosy 95

Chapter 7 The Kinetoplastid Infections: Human African Trypanosomiasis (Sleeping Sickness), American Trypanosomiasis (Chagas Disease), and the Leishmaniases 111

Chapter 8 The Urban Neglected Tropical Diseases: Leptospirosis, Dengue and Zika, and Rabies 143

Chapter 9 The Neglected Tropical Diseases of North America 159

Chapter 10 Uniting to Combat Neglected Tropical Diseases, and a New WHO Roadmap (20212030) 181

Chapter 11 Future Trends in Control of Neglected Tropical Diseases and the Antipoverty Vaccines 203

Chapter 12 The Newest NTDs and a Plea to Repair the World 217

Appendix: What Are the Neglected Tropical Diseases? 227

Index 229

About the Author 239