This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response. The book is divided into three sections, the first of which examines the most recent thinking on treatment resistance in psychiatry, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or functional connectivity, and insights from animal models. The second section then discusses treatment resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, more detailed information is presented on diverse pharmacological and non-pharmacological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of management for treatment resistance in psychiatric disorders.

Yong-Ku Kim, MD, PhDDepartment of Psychiatry, Korea University Ansan Hospital, South Korea 

Part I. Rethinking the treatment resistance in psychiatry.- Chapter 1. Definition and epidemiology of treatment resistance in psychiatry.- Chapter 2. Paradigm shift in study of treatment resistant psychiatric disorder.- Chapter 3. Genetic factors underlying treatment resistance in psychiatry.- Chapter 4. Using neuroimaging and electroencephalography for prediction of treatment resistance in psychiatric disorders.- Chapter 5. Developing therapies for treatment-resistant depressive disorders in animal models.- Chapter 6. Integrated approaches to treatment-resistant psychiatric disorders.- Part II. Treatment resistance in specific disorders.- Chapter 7. Treatment resistant depression: understandings on the neurobiological etiology that lead to novel pharmacological treatment options.- Chapter 8. Treatment Resistant Schizophrenia: assessment and management.- Chapter 9. Treatment resistance in bipolar disorders.- Chapter 10. Treatment resistance in post-traumatic stress disorder.- Chapter 11. Treatment resistance in obsessive compulsive disorder.- Chapter 12. Treatment of opioid dependence.- Chapter 13. Treatment-resistant panic disorder.- Chapter 14. Treatment resistance in anxiety disorder: generalized anxiety disorder, social anxiety disorder.- Chapter 15. Treatment resistance in Attention-Deficit Hyperactivity Disorder.- Chapter 16. Treatment resistance in Tourette syndrome.- Chapter 17. Treatment-Resistance Eating Disorders.- Chapter 18. Comorbid sleep and wake problems in treatment-resistant psychiatric conditions.- Part III. Therapeutic intervention for treatment resistance.- Chapter 19. Creative, person-centered psychopharmacology for treatment resistance in psychiatry.- Chapter 20. A psychodynamic approach to treatment resistance.- Chapter 21. Cognitive behavioral therapy and behavioral activation therapy for treatment resistant depression: traditional and digital therapy perspectives.- Chapter 22. Novel neurostimulation therapeutic approaches for treatmentresistant psychiatric disorders.- Chapter 23. When clozapine fails: augmentation strategies in the management of clozapine-resistant schizophrenia.- Chapter 24. Fecal microbiota transplantation in the treatment resistant psychiatric disorders.- Chapter 25. Neurosurgical intervention for treatment-resistant psychiatric disorders.